Adverse childhood experiences may increase the risk of migraine onset in adolescence


Background: Adverse childhood experiences (ACEs) are cross-sectionally associated with headache, including migraine, in pediatric populations.

Objective: The objective of this study was to determine whether ACEs are prospectively associated with incident health-professional diagnosed migraine and prevalence of non-migraine frequent headache in adolescence, either directly or indirectly through symptoms of depression and anxiety.