Can cardiovascular risk factors be modulated to reduce risk of Alzheimer’s disease progression in older adults?


  • Early interventions to reduce the modifiable cardiovascular risk factors could be beneficial to cognitively normal elderly adults who are β-amyloid (Aβ) negative.

Why this matters

  • The Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is used to calculate dementia risk, considering age, gender, apolipoprotein E (APOE) ε4 status, education, hypertension, body mass index, hypercholesterinemia and physical inactivity. However, the CAIDE risk score has limitations, due to the inclusion of unmodifiable risk factors, such as age and APOE ε4. 

  • The findings of this study supported that intervention to reduce Alzheimer’s disease (AD) risk by modulating vascular risk factors at early stage before patients reached abnormal level of Aβ. Also, the results have crucial implications for clinicopathological models of AD.